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Test ID NBLD0415 Orotic Acid, Urine

Reporting Name

Orotic Acid, U

Useful For

Evaluation of the differential diagnosis of hyperammonemia and hereditary orotic aciduria

 

When orotic acid is measured after a protein load or administration of allopurinol, excretion of orotic acid is a very sensitive indicator of ornithine transcarbamylase (OTC) activity. An allopurinol challenge may be helpful in determining whether a female patient may be a carrier of an OTC mutation if molecular genetic testing was not informative.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Urine


Necessary Information


Patient's age is required.



Specimen Required


Container/Tube: Plastic, 10-mL urine tube (T068)

Specimen Volume: 10 mL

Collection Instructions:

1. Collect a random or timed urine specimen.

2. No preservative.


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen 30 days

Reference Values

<2 weeks: 1.4-5.3 mmol/mol creatinine

2 weeks-1 year: 1.0-3.2 mmol/mol creatinine

2-10 years: 0.5-3.3 mmol/mol creatinine

≥11 years: 0.4-1.2 mmol/mol creatinine

Day(s) and Time(s) Performed

Wednesday; 8 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83921

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OROT Orotic Acid, U In Process

 

Result ID Test Result Name Result LOINC Value
8905 Orotic Acid, U 30480-8

Analytic Time

8 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Method Name

Colorimetric